The Stability Optimizer

Capstone challenge for Module 9: The Optimizer. Diagnose weak points in T4 lysozyme across five diagnostic views, without hints.

• Diagnose weak points in T4 lysozyme across five diagnostic views, without hints
• Propose stabilising mutations and justify each against the published stability literature
• Recognise when the most famous site in a protein is not the best move
• Keep the catalytic residues intact while raising stability