9.3 Structural Diagnostics

Structural Diagnostics (Module 9: The Optimizer). Key concept: Systematic identification of stability weak points. Diagnose several stability problems in one protein systematically.

• Diagnose several stability problems in one protein systematically
• Identify cavities, buried charges, unsatisfied hydrogen bonds, exposed patches and mobile loops
• Classify each defect by type using the five diagnostic views
• Recognise that a prediction confidence score is not a flexibility measurement