9.4 Energy Landscapes

Energy Landscapes (Module 9: The Optimizer). Key concept: Native state as global energy minimum. Read a folding funnel and explain what its depth and width represent.

• Read a folding funnel and explain what its depth and width represent
• Recognise kinetic traps and shallow funnels, and what each one predicts experimentally
• Explain what a stabilising mutation changes on the landscape — deepening the native well, or raising the unfolded state