6.3 Why Designs Fail

Why Designs Fail (Module 6: The Experimentalist). Key concept: Common failure modes. Analyse a design for known failure modes before any experimental result exists.

• Analyse a design for known failure modes before any experimental result exists
• Identify the red flags: buried charges, exposed patches, rare codons, wrong oligomeric state, marginal folds
• Predict the specific way a given design will fail
• Build the habit of interrogating a design rather than trusting the tool that produced it