3.integration The Protein Repair Shop

The Protein Repair Shop (Module 3: The Architect). Key concept: Integration exercise. Diagnose several independent structural problems in one protein.

• Diagnose several independent structural problems in one protein
• Identify buried charges, missing disulfides and exposed hydrophobic patches from residue identity and position
• Choose a targeted replacement residue for each defect
• Explain how electrostatics, covalent bonding and hydrophobicity contribute to stability independently