3.4 Domain Architecture

Domain Architecture (Module 3: The Architect). Key concept: Structural domains & motifs. Explain what makes a domain an independently folding unit.

• Explain what makes a domain an independently folding unit
• Recognise linkers as flexible connectors, often glycine- and proline-rich
• Locate domain boundaries from thin connection points, changes in structural character and flexibility
• Explain why boundaries matter: independent redesign, prediction interpretation, and modular function