11.4 Developability

Developability (Module 11: The Healer). Key concept: Stability, solubility, expressibility, safety. Assess a protein against all four therapeutic criteria at once.

• Assess a protein against all four therapeutic criteria at once
• Apply mutations that move a specific metric, and read what they cost elsewhere
• Navigate trade-offs where no single mutation improves everything
• Keep predicted effect sizes honest: single substitutions buy about 1 to 3 °C, not 6