Module 11: The Healer

Therapeutic Design

Complete the full protein design pipeline for therapeutic applications.

• Evaluate a disease target for druggability from structure and conservation data
• Select hotspot residues that are both constrained and clustered, knowing conservation buys time rather than permanence
• Find and remove T-cell epitopes without damaging the fold that carries them
• Navigate the trade-offs between stability, solubility, expressibility and immunogenicity
• Run the whole therapeutic pipeline, from target to a justified viability assessment