11.2 Target Selection

Target Selection (Module 11: The Healer). Key concept: Targets must be disease-relevant and druggable. Interpret a structure in therapeutic context.

• Interpret a structure in therapeutic context
• Characterise a protein–protein interface and identify its contact residues
• Select hotspot residues on conservation, exposure and spatial clustering together
• Explain why conservation measures what a pathogen has not yet changed, not what it cannot change — and what that means for a binder