The Peptide Engineer

Capstone challenge for Module 1: The Building Blocks. Balance charge across a designed peptide to reach net neutrality.

• Balance charge across a designed peptide to reach net neutrality
• Choose hydrophobic residues that give the core a stable centre
• Position charged pairs at salt-bridge distance
• Place aromatics in a stacking geometry that is actually favourable
• Satisfy all four constraints at once without introducing steric clashes