1.3 Size & Shape: The Packing Game

Size & Shape: The Packing Game (Module 1: The Building Blocks). Key concept: Steric complementarity. Compare side chains by volume and shape, not just by polarity.

• Compare side chains by volume and shape, not just by polarity
• Explain why tight packing in the core is as important as burial itself
• Recognise cavities as a destabilising defect rather than empty space
• Match residues to pockets by size, and predict what a mismatch costs