Target Acquisition

Capstone challenge for Module 5: The Explorer. Identify the most druggable pocket on a viral protease surface.

• Identify the most druggable pocket on a viral protease surface
• Characterise that pocket by size, chemical character, charge and hydrogen bonding potential
• Choose the best-fitting ligand and justify it from shape and chemistry
• Propose binding-improving mutations with a biochemical rationale
• Run the whole Module 5 workflow as a realistic target analysis