5.2 Surface Topography and Pocket Detection

Surface Topography and Pocket Detection (Module 5: The Explorer). Key concept: Binding pockets, surface shape, and druggability. Explain why binding sites are concave and what a pocket actually is.

• Explain why binding sites are concave and what a pocket actually is
• Locate pockets on a molecular surface
• Explain how depth, hydrophobicity and polarity decide what a pocket can bind
• Distinguish a druggable pocket from one that merely exists