10.3 Interface Design Principles

Interface Design Principles (Module 10: The Assembler). Key concept: Stable interfaces need BSA, shape complementarity, H-bonds. Engineer an interface with enough buried surface area to hold a complex together.

• Engineer an interface with enough buried surface area to hold a complex together
• Balance hydrophobic contact, hydrogen bonding, shape complementarity and clashes
• State the buried surface area convention you are using: roughly 600 Ų per chain is a floor, and a designed homodimer usually wants 800–1000