10.1 Why Multimerize?

Why Multimerize? (Module 10: The Assembler). Key concept: Multi-chain complexes enable regulation and cooperativity. Explain the advantages a protein gains by assembling from several chains.

• Explain the advantages a protein gains by assembling from several chains
• Identify the four reasons proteins multimerise: cooperativity, efficient self-assembly, division of labour, and de novo assembly design
• Recognise quaternary structure in haemoglobin, antibodies and viral capsids