# 9.2 B-Factors and Flexibility

> B-Factors and Flexibility (Module 9: The Optimizer). Key concept: B-factors indicate flexibility. Read B-factors to separate mobile regions from rigid ones.

B-Factors and Flexibility (Module 9: The Optimizer). Key concept: B-factors indicate flexibility. Read B-factors to separate mobile regions from rigid ones.

- Read B-factors to separate mobile regions from rigid ones
- Identify a flexible loop that is a stability liability rather than a functional feature
- Recognise that a chain terminus is often but not always mobile — read the map instead of assuming
- Distinguish disorder that reports on function from disorder that reports on where the chain stops

## Links

- [Module 9: The Optimizer](https://proteindesign.academy/module/9)
- [Introduction](https://proteindesign.academy/module/9/intro)
- [9.1 Proteins in Motion](https://proteindesign.academy/module/9/1)
- [9.3 Structural Diagnostics](https://proteindesign.academy/module/9/3)
- [9.4 Energy Landscapes](https://proteindesign.academy/module/9/4)
- [9.5 Thermostability Engineering](https://proteindesign.academy/module/9/5)
- [9.integration The Guided Repair](https://proteindesign.academy/module/9/integration)
- [The Stability Optimizer](https://proteindesign.academy/module/9/capstone)
- [Use the Tools](https://proteindesign.academy/module/9/tools)