# 8.1 What Is De Novo Design?

> What Is De Novo Design? (Module 8: The Creator). Key concept: Creating proteins with no evolutionary ancestor. Explain what de novo design means: a protein with no evolutionary ancestor.

What Is De Novo Design? (Module 8: The Creator). Key concept: Creating proteins with no evolutionary ancestor. Explain what de novo design means: a protein with no evolutionary ancestor.

- Explain what de novo design means: a protein with no evolutionary ancestor
- Survey what the field builds with it — binders, cages, enzymes and scaffolds
- Trace the line from Top7 to the SARS-CoV-2 miniprotein inhibitors
- Explain why binder design is the application this module follows

## Links

- [Module 8: The Creator](https://proteindesign.academy/module/8)
- [Introduction](https://proteindesign.academy/module/8/intro)
- [8.2 How Diffusion Models Work](https://proteindesign.academy/module/8/2)
- [8.3 Hotspot Definition](https://proteindesign.academy/module/8/3)
- [8.4 RFdiffusion: The Full Tool](https://proteindesign.academy/module/8/4)
- [The Binder Generator](https://proteindesign.academy/module/8/capstone)
- [Use the Tools](https://proteindesign.academy/module/8/tools)