# 7.3 Solubility Surgeon

> Solubility Surgeon (Module 7: The Sequence Finder). Key concept: Engineering surface properties. Identify the surface hydrophobic patches that drive aggregation.

Solubility Surgeon (Module 7: The Sequence Finder). Key concept: Engineering surface properties. Identify the surface hydrophobic patches that drive aggregation.

- Identify the surface hydrophobic patches that drive aggregation
- Redesign the surface for solubility without disturbing the core
- Track how hydrophobic surface penalty, net charge and core integrity each move the score

## Links

- [Module 7: The Sequence Finder](https://proteindesign.academy/module/7)
- [Introduction](https://proteindesign.academy/module/7/intro)
- [7.1 Sequence Space](https://proteindesign.academy/module/7/1)
- [7.2 The Degeneracy Principle](https://proteindesign.academy/module/7/2)
- [7.4 ProteinMPNN: How It Works](https://proteindesign.academy/module/7/4)
- [7.5 Evaluating MPNN Outputs](https://proteindesign.academy/module/7/5)
- [7.integration The Sequence Swap](https://proteindesign.academy/module/7/integration)
- [The MPNN Challenge](https://proteindesign.academy/module/7/capstone)
- [Use the Tools](https://proteindesign.academy/module/7/tools)