# 7.2 The Degeneracy Principle

> The Degeneracy Principle (Module 7: The Sequence Finder). Key concept: Conservation vs variation. Discover that core positions are tightly constrained while surface positions vary freely.

The Degeneracy Principle (Module 7: The Sequence Finder). Key concept: Conservation vs variation. Discover that core positions are tightly constrained while surface positions vary freely.

- Discover that core positions are tightly constrained while surface positions vary freely
- Explain why structure constrains sequence asymmetrically
- Classify positions as conserved or variable, and check the call against burial

## Links

- [Module 7: The Sequence Finder](https://proteindesign.academy/module/7)
- [Introduction](https://proteindesign.academy/module/7/intro)
- [7.1 Sequence Space](https://proteindesign.academy/module/7/1)
- [7.3 Solubility Surgeon](https://proteindesign.academy/module/7/3)
- [7.4 ProteinMPNN: How It Works](https://proteindesign.academy/module/7/4)
- [7.5 Evaluating MPNN Outputs](https://proteindesign.academy/module/7/5)
- [7.integration The Sequence Swap](https://proteindesign.academy/module/7/integration)
- [The MPNN Challenge](https://proteindesign.academy/module/7/capstone)
- [Use the Tools](https://proteindesign.academy/module/7/tools)