# Introduction

> Understand that a computationally designed protein is a hypothesis, not a product. Learn what determines whether a design actually works when expressed in a cell, and develop the critical thinking to anticipate failure modes.

Understand that a computationally designed protein is a hypothesis, not a product. Learn what determines whether a design actually works when expressed in a cell, and develop the critical thinking to anticipate failure modes.

## Links

- [Module 6: The Experimentalist](https://proteindesign.academy/module/6)
- [6.1 Expression Systems](https://proteindesign.academy/module/6/1)
- [6.2 The Solubility Problem](https://proteindesign.academy/module/6/2)
- [6.3 Why Designs Fail](https://proteindesign.academy/module/6/3)
- [6.4 The Validation Pipeline](https://proteindesign.academy/module/6/4)
- [The Expressibility Audit](https://proteindesign.academy/module/6/capstone)
- [Use the Tools](https://proteindesign.academy/module/6/tools)