# The Expressibility Audit

> Capstone challenge for Module 6: The Experimentalist. Evaluate four designed sequences and their predicted structures for real-world viability.

Capstone challenge for Module 6: The Experimentalist. Evaluate four designed sequences and their predicted structures for real-world viability.

- Evaluate four designed sequences and their predicted structures for real-world viability
- Predict which will express in E. coli and which will not
- Identify the specific red flags in each problematic design
- Propose mutations that fix expressibility without breaking function

## Links

- [Module 6: The Experimentalist](https://proteindesign.academy/module/6)
- [6.1 Expression Systems](https://proteindesign.academy/module/6/1)
- [6.2 The Solubility Problem](https://proteindesign.academy/module/6/2)
- [6.3 Why Designs Fail](https://proteindesign.academy/module/6/3)
- [6.4 The Validation Pipeline](https://proteindesign.academy/module/6/4)