# 6.3 Why Designs Fail

> Why Designs Fail (Module 6: The Experimentalist). Key concept: Common failure modes. Analyse a design for known failure modes before any experimental result exists.

Why Designs Fail (Module 6: The Experimentalist). Key concept: Common failure modes. Analyse a design for known failure modes before any experimental result exists.

- Analyse a design for known failure modes before any experimental result exists
- Identify the red flags: buried charges, exposed patches, rare codons, wrong oligomeric state, marginal folds
- Predict the specific way a given design will fail
- Build the habit of interrogating a design rather than trusting the tool that produced it

## Links

- [Module 6: The Experimentalist](https://proteindesign.academy/module/6)
- [6.1 Expression Systems](https://proteindesign.academy/module/6/1)
- [6.2 The Solubility Problem](https://proteindesign.academy/module/6/2)
- [6.4 The Validation Pipeline](https://proteindesign.academy/module/6/4)
- [The Expressibility Audit](https://proteindesign.academy/module/6/capstone)