# Target Acquisition

> Capstone challenge for Module 5: The Explorer. Identify the most druggable pocket on a viral protease surface.

Capstone challenge for Module 5: The Explorer. Identify the most druggable pocket on a viral protease surface.

- Identify the most druggable pocket on a viral protease surface
- Characterise that pocket by size, chemical character, charge and hydrogen bonding potential
- Choose the best-fitting ligand and justify it from shape and chemistry
- Propose binding-improving mutations with a biochemical rationale
- Run the whole Module 5 workflow as a realistic target analysis

## Links

- [Module 5: The Explorer](https://proteindesign.academy/module/5)
- [5.1 Molecules 101: What Proteins Bind](https://proteindesign.academy/module/5/1)
- [5.2 Surface Topography and Pocket Detection](https://proteindesign.academy/module/5/2)
- [5.3 Electrostatic Surfaces](https://proteindesign.academy/module/5/3)
- [5.4 Shape Complementarity](https://proteindesign.academy/module/5/4)
- [5.5 Enzyme Catalysis: The Catalytic Triad](https://proteindesign.academy/module/5/5)
- [5.integration Design a Binding Site](https://proteindesign.academy/module/5/integration)