# 3.integration The Protein Repair Shop

> The Protein Repair Shop (Module 3: The Architect). Key concept: Integration exercise. Diagnose several independent structural problems in one protein.

The Protein Repair Shop (Module 3: The Architect). Key concept: Integration exercise. Diagnose several independent structural problems in one protein.

- Diagnose several independent structural problems in one protein
- Identify buried charges, missing disulfides and exposed hydrophobic patches from residue identity and position
- Choose a targeted replacement residue for each defect
- Explain how electrostatics, covalent bonding and hydrophobicity contribute to stability independently

## Links

- [Module 3: The Architect](https://proteindesign.academy/module/3)
- [3.1 Building the Hydrophobic Core](https://proteindesign.academy/module/3/1)
- [3.2 Disulfide Bridges](https://proteindesign.academy/module/3/2)
- [3.3 Surface vs Buried: The Inside-Out Rule](https://proteindesign.academy/module/3/3)
- [3.4 Domain Architecture](https://proteindesign.academy/module/3/4)
- [The Folding Architect](https://proteindesign.academy/module/3/capstone)