# 3.4 Domain Architecture

> Domain Architecture (Module 3: The Architect). Key concept: Structural domains & motifs. Explain what makes a domain an independently folding unit.

Domain Architecture (Module 3: The Architect). Key concept: Structural domains & motifs. Explain what makes a domain an independently folding unit.

- Explain what makes a domain an independently folding unit
- Recognise linkers as flexible connectors, often glycine- and proline-rich
- Locate domain boundaries from thin connection points, changes in structural character and flexibility
- Explain why boundaries matter: independent redesign, prediction interpretation, and modular function

## Links

- [Module 3: The Architect](https://proteindesign.academy/module/3)
- [3.1 Building the Hydrophobic Core](https://proteindesign.academy/module/3/1)
- [3.2 Disulfide Bridges](https://proteindesign.academy/module/3/2)
- [3.3 Surface vs Buried: The Inside-Out Rule](https://proteindesign.academy/module/3/3)
- [3.integration The Protein Repair Shop](https://proteindesign.academy/module/3/integration)
- [The Folding Architect](https://proteindesign.academy/module/3/capstone)