# 11.4 Developability

> Developability (Module 11: The Healer). Key concept: Stability, solubility, expressibility, safety. Assess a protein against all four therapeutic criteria at once.

Developability (Module 11: The Healer). Key concept: Stability, solubility, expressibility, safety. Assess a protein against all four therapeutic criteria at once.

- Assess a protein against all four therapeutic criteria at once
- Apply mutations that move a specific metric, and read what they cost elsewhere
- Navigate trade-offs where no single mutation improves everything
- Keep predicted effect sizes honest: single substitutions buy about 1 to 3 °C, not 6

## Links

- [Module 11: The Healer](https://proteindesign.academy/module/11)
- [Introduction](https://proteindesign.academy/module/11/intro)
- [11.1 Therapeutic Protein Design](https://proteindesign.academy/module/11/1)
- [11.2 Target Selection](https://proteindesign.academy/module/11/2)
- [11.3 De-immunization](https://proteindesign.academy/module/11/3)
- [11.integration The Drug Pipeline](https://proteindesign.academy/module/11/integration)
- [The Therapeutic Designer](https://proteindesign.academy/module/11/capstone)
- [Use the Tools](https://proteindesign.academy/module/11/tools)