# 10.3 Interface Design Principles

> Interface Design Principles (Module 10: The Assembler). Key concept: Stable interfaces need BSA, shape complementarity, H-bonds. Engineer an interface with enough buried surface area to hold a complex together.

Interface Design Principles (Module 10: The Assembler). Key concept: Stable interfaces need BSA, shape complementarity, H-bonds. Engineer an interface with enough buried surface area to hold a complex together.

- Engineer an interface with enough buried surface area to hold a complex together
- Balance hydrophobic contact, hydrogen bonding, shape complementarity and clashes
- State the buried surface area convention you are using: roughly 600 Ų per chain is a floor, and a designed homodimer usually wants 800–1000

## Links

- [Module 10: The Assembler](https://proteindesign.academy/module/10)
- [Introduction](https://proteindesign.academy/module/10/intro)
- [10.1 Why Multimerize?](https://proteindesign.academy/module/10/1)
- [10.2 Symmetry in Protein Assemblies](https://proteindesign.academy/module/10/2)
- [10.4 Evaluating Assemblies](https://proteindesign.academy/module/10/4)
- [10.integration The Assembly Blueprint](https://proteindesign.academy/module/10/integration)
- [The Assembly Designer](https://proteindesign.academy/module/10/capstone)
- [Use the Tools](https://proteindesign.academy/module/10/tools)